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CCL2 helps promote the recruitment and differentiation of Ly6C+ monocytes to M1 macrophages as part of the proinflammatory cascade.

  • This approach has yielded mixed findings, where higher estradiol concentrations are shown to reduce ; ; ; ; ; ; , increase ; ; ; ; , or have no effect on the inflammatory response ; ;.

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The biological cues that activate SC can originate from several sources within the immediate extracellular space: soluble factors in circulation, adjacent muscle fibers, fibroblasts, endothelial cells, and leukocytes, to name just a few.

  • The current study presents novel findings on sex-based differences in the myogenic response to the same relative load of damaging exercise, adding to the existing literature on damaging exercise and highlighting a potential mechanistic link between satellite cells and the muscle damage response in males and females.




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