Copyright © 2021 Elsevier Inc.
Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by sotrovimab.
F Particles bearing the indicated S proteins were inoculated onto different cell lines, and S-protein-driven cell entry was analyzed at 16—18 h postinoculation by measuring the activity of virus-encoded firefly luciferase in cell lysates.
The Omicron spike mediates entry into cell lines with different efficiency as compared with B.